il-4 can inhibit il-17 production in collagen induced arthritis
نویسندگان
چکیده
background: il-4 is a cytokine that induces differentiation of naive helper t cells into th2 cells. once activated by il-4, th2 cells subsequently produce additional il-4. objective: to examine the effect of il-4 on il-17 production and its effect in collagen- induced arthritis (cia) mice. method: in this study, a chicken collagen-ii-induced experimental arthritis (cia) model was used in dba/1 mice to investigate the relationship between il-4 and il-17 as well as other inflammatory factors. on the 38th day after the mice were induced with cia, the expression of il-17 and il-4 as well as ifn-γ and il-13 in sera of the mice was measured by qrt-pcr and elisa. result: the result of qrt-pcr analysis of il-17 and il-4 mrna levels in the spleen showed that il-17 is increased significantly at the onset of cia in the spleen (p
منابع مشابه
IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis
Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice. Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...
متن کاملIL-4 can inhibit IL-17 production in collagen induced arthritis.
BACKGROUND IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. OBJECTIVE To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis (CIA) mice. METHOD In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...
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عنوان ژورنال:
iranian journal of immunologyجلد ۸، شماره ۴، صفحات ۲۰۹-۲۱۷
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